The "X Factor" boss was given the accolade in recognition of his outstanding contribution to music and entertainment, as well as his charity work.
One Direction, who were discovered by Cowell and his fellow judges on the UK talent show in 2010 and subsequently signed to his Syco music label, were on hand to salute their longtime mentor with the prize, reported BBC.
"When we started on X Factor we could never have imagined how Simon would change our lives," Liam Payne told the audience.
He then joked, "Guys, who misses Zayn?," referring to former One Direction star Zayn Malik, who left the group earlier this year.
Cowell went on to dedicate the prize to his mother, who died in July, and late father, and acknowledged his two-year-old son Eric, saying, "I hope he will be standing here in 23 years time as I'm being wheeled into the Grosvenor House Hotel on my second pack of cigarettes."
Other former "X Factor" contestants Olly Murs and Leona Lewis were also on hand to fete Cowell, alongside his label's artists Il Divo and Labrinth.
The Music Industry Trust annual gala benefits the charities Nordoff Robbins and the BRIT Trust.
Previous recipients of the organisation's top award include Elton John, Gary Barlow and Annie Lennox.
