The collision happened yesterday during night training operations over a remote military operating area in Jefferson County, Georgia, a National Guard spokeswoman said.
The jets were assigned to the South Carolina Air National Guard's 169th Fighter Wing, which operates out of McEntire Joint National Guard Base in Eastover, South Carolina.
The two male pilots were taken to a hospital, said 1st Lt Stephen Hudson, a spokesman for the Guard.
Guard spokeswoman Col Cindi King said this morning she could not say whether the pilots had been released from medical care.
There were no immediate reports of injuries on the ground. "We are dealing with two crash sites," Hudson said. Local first responders were securing the area and providing emergency services, the Guard's news release said.
McEntire Joint National Guard Base commander Col Nicholas Gentile was heading to the crash scene Wednesday morning, King said.
The South Carolina Army National Guard was flying Gentile to Georgia aboard a UH-60 Blackhawk helicopter, King said.
"With the sun out, they will be able to see the area," she said, adding that the Blackhawk helicopters will help in their ability to fly over and assess potential damage.
King said South Carolina National Guard commander Maj Gen Robert Livingston Jr was in Washington last night when he got news of the crashes and was returning to Columbia to be updated.
The South Carolina Air National Guard and the US Air Force are dispatching teams to investigate the collision.
The collision comes after both of the military's precision flying teams suffered crashes last week.
A Blue Angels F/A-18 crashed last Thursday near Nashville, Tennessee, while taking off for a practice session. The pilot, Marine Capt. Jeff Kuss, was killed.
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