The bomb was planted in a rickshaw which was parked near the mosque, police official Khaliq Sheikh said.
Three persons were killed while 22 others were injured in the blast that occurred soon after the Friday prayers in the Gizri area near the upscale Clifton locality.
This is the first time that such a major explosion has taken place in the Gizri area, close to Clifton.
"There is a deep crater near the blast but we are investigating and someone could have been a target," he said.
Geo channel reported that at least 10 vehicles, six rickshaws and many motorcycles were completely destroyed or damaged in the blast.
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