The "Trainwreck" actress made the announcement while performing an opening act for pop diva Madonna at the famed New York City venue as a part of latter's Rebel Heart Tour, said The Hollywood Reporter.
"I just found out that I'll be playing MSG by myself on June 23!" Schumer said.
The Madison Square Garden is considered a benchmark for stand-up comedy success.
The 34-year-old "Inside Amy Schumer" comedian said she was excited to perfrom the opening slot for music icon like Madonna.
