"Fifteen civilians, among them 11 children, were killed in a barrel bomb attack on the Bab al-Nayrab neighbourhood" in the south of Aleppo city, the Britain-based Syrian Observatory for Human Rights monitor said.
The group also reported eight civilians, including two children, were killed on Thursday in rebel fire on the government-held west of the city.
An AFP journalist in Bab al-Nayrab saw rescue workers and civilians digging through the rubble of collapsed buildings.
Elsewhere, a civil defence worker protected the face of another dead child as his colleagues scraped away the rubble encasing the rest of the child's body.
Syria's regime has been accused of regularly using barrel bombs -- crude, explosive devices -- on rebel-held areas that are home to civilians, and other parties to the conflict are not known to have used the weapons.
President Bashar al-Assad and his government deny using barrel bombs.
The city has been roughly divided between rebel control in the east and government control in the west since mid-2012, with each side bombarding the other and causing civilian casualties.
More than 290,000 people have been killed in Syria since the conflict began, according to the Observatory.
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