The 19-year-old entertainer, who has 12 millions followers on Instagram, is wearing a simple white T-shirt, gold chain and cap in the photograph as he poses with Smith, reported Ace Showbiz.
"Me and uncle Will," Bieber had captioned the picture, which was uploaded four months ago.
Instagram's CEO Kevin Systrom said during an appearance on a show, that there are millions of photos shared every day, but Bieber's photo with Smith garnered more than 1,496,070 "likes.