With only eight days to go before Scotland votes on whether to end the 300-year-old union, Cameron and opposition Labour leader Ed Miliband agreed to skip their weekly debate in the House of Commons and travel north of the border.
The sudden move, announced only a day earlier, reflects a new sense of urgency in the unionist camp after recent polls showed the two sides of the debate were now neck-and-neck.
"So let no one in Scotland be in any doubt: we desperately want you to stay; we do not want this family of nations to be ripped apart.
"If the UK breaks apart, it breaks apart forever. So the choice for you is clear: a leap into the dark with a Yes vote, or a brighter future for Scotland by voting No. You can have the best of both worlds in the UK."
Liberal Democrat leader Nick Clegg, the deputy prime minister in the coalition government, will also hit the campaign trail.
But a YouGov poll at the weekend set the cat among the pigeons, putting the pro-independence "Yes" camp ahead for the first time, while another yesterday showed the two sides were tied.
In response, all three major parties unveiled a timetable for the transfer of new powers over income tax and welfare spending to the devolved Scottish government, and said work would begin immediately after a "No" vote.
First Minister Alex Salmond, the leader of the Scottish National Party (SNP), dismissed the initiative as a "back-of-an-envelope non-plan".
"The 'No' campaign think that they are losing this campaign -- and these hugely distrusted Westminster leaders trooping up to Scotland is only going to boost that process," he said.
Cameron's Conservatives are not popular in Scotland -- they have just one Scottish member of parliament out of 59 and he is trusted by just 23 percent of Scots, according to a recent YouGov poll.
Miliband's Labour party has a stronger presence in Scotland, but he has the same dismal personal rating.
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