According to government of Wuhu city in Anhui province, the accident happened when a bus overturned into the opposite lane on a highway and was hit by a truck coming from opposite direction.
Ten people died and many others were injured in the crash, the Wuhu information department said in a statement, without providing the exact number of those injured.
An inquiry has been ordered into the crash, state-run Xinhua news agency reported.
Road accidents in China are common and are often caused by violation of traffic rules, poor driving, inadequate maintenance and overloading.
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