The Charles Dickens Museum in London has been given the grant to buy the desk and chair, which has always been in private ownership.
They had been passed down through the Dickens family after his death in 1870, but were auctioned for the Great Ormond Street Charitable Trust in 2004.
Dickens used the desk in his final home in Gad's Hill Place in Kent.
'Our Mutual Friend' and his unfinished novel 'The Mystery of Edwin Drood' were also penned at the desk.
Made famous in two paintings begun the year he died, the 'Empty Chair' by Luke Fildes and 'Dickens' Dream' by RW Buss, the desk and chair are already on display at the Charles Dickens Museum at the author's former home.
"We are delighted to have been able to acquire Charles Dickens' iconic writing desk and chair for permanent display in his study at 48 Doughty Street," Robert Moye, director of the Charles Dickens Museum, said.
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