The entertainment network announced that the 22-year-old star would join Daniel Bruhl and Luke Evans on the show, reported AceShowbiz.
Fanning will portray Sara Howard, a "headstrong secretary at a police headquarters."
Bruhl will star as criminal psychologist aka alienist Dr Lazlo Kreizler and Evans will essay the role of John Moore, a newspaper reporter.
Based on Caleb Carr's novel of the same name, the psychological thriller will begin the production early this year in Budapest.
Fanning's last TV appearance was on an episode of "Friends" in season 10. Her other TV credits include "Justice League Unlimited", "Family Guy" and "CSI: Crime Scene Investigation".
"The Alienist" is slated to premiere in late 2017 on TNT.
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