Del Potro, the 2009 US Open champion and Auckland winner, beat Ferrer 6-4, 6-4 to continue his strong form from the end of last season, which included victory in Stockholm and losing the Basel final to Roger Federer.
The Argentine world number 12 now goes into a final against 2016 Auckland champion Bautista Agut, who came from behind in an epic a battle against Dutchman Robin Haase featuring three tie-breaks.
"Unfortunately the match cannot have two winners and I'm so happy I won," said the relieved Spaniard, who sank to his knees at the end.
"The end was unbelievable when I saw the ball in I went crazy, I was so happy."
The pair battled for nearly three hours, in a match highlighted by long rallies mixing powerful drives into the corners with cross-court floaters.
Every weapon in their armoury was on display, with Haase even switching his racquet from the right to left hand to reach shots swinging away down the backhand side.
After del Potro raced through the first set, Ferrer held break points when leading 2-1 and 4-3 in the second set as the Argentinian, seeded 12th in the Australian Open next week, struggled with his first serve.
But both times Del Potro was able to rely on his running forehand to save himself and at 4-4 he broke the Spaniard before successfully serving for the match.
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