Syria's former Al-Qaeda affiliate Fateh al-Sham Front claimed the spectacular attack which targeted and killed Gen Hassan Daabul, a close confidant of President Bashar al-Assad.
The Syrian Observatory for Human Rights said 42 people were killed when the bombers targeted the headquarters of state security and military intelligence in the heavily guarded Ghouta and Mahatta neighbourhoods.
Provincial governor Talal Barazi said 30 people were killed and 24 wounded.
State television confirmed Daabul's death, saying that the general had been specifically targeted by one of the suicide bombers.
Observatory chief Rami Abdel Rahman said they lasted two hours.
Fateh al-Sham said five of its militants took part in the assault. State television and the Observatory spoke of six bombers.
Homs has been under the full control of the government since May 2014 when rebels withdrew from the centre under a UN-brokered truce deal.
But it has seen repeated bombings since then. Twin attacks killed 64 people early last year.
Like its jihadist rival, the Islamic State group, Fateh al-Sham is not party to a ceasefire between government forces and rebel groups taking part in the Geneva talks.
The group overran almost all of the northwestern province of Idlib in 2015 in alliance with Islamist rebels.
But relations have since frayed as its allies have joined peace negotiations with the government, first in Kazakhstan earlier this year and then in Geneva.
Fateh al-Sham has meanwhile been targeted by intensifying air strikes, not just by the government but also by its ally Russia and by the US-led coalition fighting IS.
Scores of its fighters have been killed since the start of the year.
Today's attack comes as the UN is struggling to get the new round of peace talks in Geneva off the ground aimed at ending the six-year civil war which has killed more than 310,000 people.
Disclaimer: No Business Standard Journalist was involved in creation of this content
You’ve reached your limit of {{free_limit}} free articles this month.
Subscribe now for unlimited access.
Already subscribed? Log in
Subscribe to read the full story →
Smart Quarterly
₹900
3 Months
₹300/Month
Smart Essential
₹2,700
1 Year
₹225/Month
Super Saver
₹3,900
2 Years
₹162/Month
Renews automatically, cancel anytime
Here’s what’s included in our digital subscription plans
Exclusive premium stories online
Over 30 premium stories daily, handpicked by our editors


Complimentary Access to The New York Times
News, Games, Cooking, Audio, Wirecutter & The Athletic
Business Standard Epaper
Digital replica of our daily newspaper — with options to read, save, and share


Curated Newsletters
Insights on markets, finance, politics, tech, and more delivered to your inbox
Market Analysis & Investment Insights
In-depth market analysis & insights with access to The Smart Investor


Archives
Repository of articles and publications dating back to 1997
Ad-free Reading
Uninterrupted reading experience with no advertisements


Seamless Access Across All Devices
Access Business Standard across devices — mobile, tablet, or PC, via web or app
