It is early days in negotiations, and that the daytime show could morph into more of a docu-series before all is said and done, reported TheWrap.
Barrymore is known for her famed chatshow appearances - once flashing David Letterman while dancing on top of his desk.
More recently, she helped friend Chelsea Handler kick off the comic's own new Netflix chatshow.
Barrymore has also joined forces with Netflix as well for "Santa Clarita Diet", a dark comedy that will pair her with "Justified" star Timothy Olyphant.
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