The fantasy-epic revolves around an ordinary teenager Meg (Storm Reid) who embarks on a journey to find his missing scientist father (Chris Pine).
Three celestial beings -- the philosophising Mrs Who (played by Indian origin Mindy Kaling), inquisitive Mrs Whatsit (Reese Witherspoon), and wizened Mrs Which (Oprah Winfrey) help Meg wrinkle time and space in her cosmic adventure, according to Entertainment Weekly.
The movie is an adaptation of Madeline L'Engle's 1962 novel and has been adapted by Oscar winner Jennifer Lee of "Frozen" frame.
"And through that, the story of this girl saving the world and being out there in the universe slaying the darkness, it also says a lot about slaying our own dragons."
The film is set for release on March 9, 2018.
DuVernay called the three actresses, playing the celestial guides, as the "three Mrs Doubtfires".
"My whole process with this film was, what if? With these women, I wondered, could we make them women of different ages, body types, races? Could we bring in culture, bring in history in their costumes? And in the women themselves, could we just reflect a fuller breadth of femininity?," she said.
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