New York Mayor Bill de Blasio called yesterday's incident "a tragedy of the worst kind" and his office said nine residents from the two collapsed buildings were still unaccounted for by nightfall.
Firefighters battled throughout the afternoon to extinguish the heavy fire in East Harlem, where witnesses compared the scene of twisted metal, thick white smoke and dusty rubble to a war zone.
Late yesterday the death toll was raised from three to four, said US media outlets CNN, ABC and CBS.
There were 15 apartments in the two buildings that collapsed, de Blasio and city officials told reporters near the scene at 116th Street and Park Avenue, a mainly Latino community.
Around 15 minutes before the blast, energy company Con Edison received a call from an adjoining apartment building alerting maintenance staff to the smell of gas.
The explosion struck around 9:30 am (1330 GMT) and the New York Fire Department said firefighters were on the scene two minutes later.
It was the first deadly disaster of its kind to strike the city of eight million since the Democrat took office in January and will raise concerns about safety in less affluent neighborhoods.
"There is a tremendous amount of anxiety, but suffice it to say that every effort is being expended to locate each and every one of these (missing) individuals," the mayor said.
The death toll rose to three as dusk fell, a spokesman for New York Fire Department told AFP.
Lamenting the "deeply unfortunate incident," the ministry said in a brief statement that Mexican consular staff remain in close contact with New York authorities.
Four different hospitals told AFP they treated a total of 63 patients, the vast majority with minor injuries.
A spokesman for Mount Sinai hospital said 22 people, including three children, were treated. Nineteen were discharged.
One woman was "critical but stable" with head trauma and two other people were still being evaluated in the emergency room, the spokesman said.
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