Nitin (55kg), Yogesh (66kg), Harpreet Singh (84kg) and Sonu (120kg) were all knocked out in their opening bouts at Arena Armeetz.
Indian women wrestlers will be in action tomorrow followed by the men's freestyle competition.
Nitin was matted by Japan's Shinobu Ota in little over a minute through a fall.
Yogesh lost to Hungary's Michel Daher. Daher took a substantial 5-0 lead in the first period. However, Yogesh fought hard in the second period but lost the bout with a cumulative score of 3-8.
On the opening day, Santosh Kumar Yadav (50kg) lost in the repecharge round of the championships yesterday.
In another encounter yesterday, Pritam Shamarao (60kg) Khot lost to Latvia's Nikita Masjuks in the second round after registering a comfortable win over Lishuai Cheng of China his opening bout.
Gupreet Singh (74kg) too exited in the second round while Praveen Dagar made an early exit after going down tamely to Romas Fridrikas of Lithuania in the 96kg category.
