The 49-year-old took part on "Jimmy Kimmel Live!" host's best known segments, Mean Tweets, where she read out one that was all about her chest.
Berry, 49, looked fabulous in a sheer and high-necked top but her attire did not go well with one of the viewers, who posted online, "Halle Berry's boobs are lopsided."
The actress immediately hit back, saying, "Well, when they're real, that happens."
Other celebrities to take part in the stint included Tobey Maguire and Naomi Watts.
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