The person died from Guillain-Barre syndrome yesterday, a neurological disorder that results from the body's immune system attacking part of the nervous system, leading to muscle weakness which can be severe or fatal.
Honduras' deputy health minister, Francis Contreras, did not identify the victim, but said he or she was among 57 patients diagnosed with Guillain-Barre.
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Although Zika has not been definitively proved to cause Guillain-Barre or microcephaly, a severe deformation of baby's brains, the World Health Organisation strongly suspects it does.
Contreras said Honduras has diagnosed 185 pregnant women with Zika.
He said more than 27,000 people in the country were affected by the illness and dengue and chikungunya, two other diseases transmitted by the Aedes aegypti mosquito.
There is currently no vaccine for the Zika virus, and affected countries are focusing on wiping out mosquito populations in an effort to curb its spread.
According to the World Health Organisation, 41 countries or territories have reported transmission of Zika within their borders since last year, and nine have reported an increase in Guillain-Barre cases.
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