The Improvised Explosive Device (IED) which had been planted on the roadside exploded near a security personnel check post in Khyber's Tirah Valley.
Two security personnel were killed in the blast, officials said.
Meanwhile, in a separate incident 12 people including four children were injured in an explosion in Began Bazar area of Lower Kurram Agency near the Pak-Afghan border.
Khyber is one of Pakistan's seven semi-autonomous regions governed by tribal laws and lies near the Afghan border.
Pakistani troops have been engaged in a full-scale offensive against Taliban and other militants in North Waziristan region under an operation named 'Zarb-i-Azb', and also in Khyber, named Khyber-1.
The Taliban and its allies have been waging an insurgency for more than a decade in Pakistan, seeking to install their own brand of fundamentalist Islamic rule.
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