The world health body said the figure is in addition to 250 million smokers in the region.
Given the high number of users and serious health consequences of tobacco use, nations in the region have set a target for 30 per cent reduction in prevalence of current tobacco use by persons over 15 years age.
The WHO said oral cancer is the most common cancer caused by smokeless tobacco and the SE-Asia Region carries the highest burden of oral cancer with over 95,000 oral cancer cases each year.
Oral cancer affects the poor, who have a greater exposure to smokeless tobacco.
Studies in Bangladesh, India, Indonesia, Sri Lanka and Thailand have shown that both smoking and use of smokeless tobacco are more prevalent among the less educated and illiterate population.
Smokeless tobacco is associated with a 2-4 times increase in risk for cardiovascular diseases. Asian studies indicate that mortality risk for women who consume smokeless tobacco is higher than that for men. Use of smokeless tobacco in pregnancy is linked to stillbirths and has 2-3 times higher risk of low birth weight babies.
