The largest international police organisation put out the public appeal from its base in Lyon, France, in a bid to bring the remaining fugitives to justice.
"People smuggling is a global issue which is why international cooperation through operations such as Hydra are essential," said Interpol's director of Operational Support Michael O'Connell in a statement announcing the programme's launch.
The operation, known as Infra Hydra, involves 44 countries as well as the EU police agency Europol, and has already made 26 arrests and located 31 other suspects, Interpol said.
Operation Hydra seeks to foster an exchange of information on the networks of smugglers and expedite investigators' work.
Anyone with information on the traffickers' possible location should contact their local police or Interpol's Fugitive Investigative Support unit, the statement said.
Interpol did not provide a timeline for its operation or the resources it would need to expand.
"The criminal networks involved have no regard for the safety or wellbeing of the people using their illegal services, they are just another commodity for them to trade, as we have seen with tragic results around the world," O'Connell said.
More than 10,000 have perished in the Mediterranean since 2014 while trying to reach Europe.
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