President Hassan Rouhani said the country will remain committed and loyal to the deal, regardless of the outcome of the US election.
Supreme Leader Ayatollah Ali Khamenei said Iran was indifferent to the result of the US vote, insisting the Iranian nation was "not worried" about the future and was ready for any fallout from the US election.
Trump's much publicized criticism of the nuclear deal and his campaign vows to renegotiate the terms and increase enforcement of the deal that put off the threat of Tehran developing atomic weapons has sent jitters across Iran.
Without mentioning Trump by name, Rouhani said that "the world is not under the will of a single individual and party. The reality of the world will impose many things on extremists."
"Nobody should imagine it is possible to play with Iran," he added.
The deal, which went into effect in January, forced Iran to pull back from the brink of nuclear weapons capacity in exchange for an end to many of the US and European sanctions that crippled Iran's economy.
It has been largely respected despite undiminished US-Iranian tensions throughout the Middle East, including their support for rival sides in Syria and Yemen's civil wars.
Trump's exact plans on the nuclear deal are vague but any renegotiation would be difficult - Iran has no incentive to reopen talks over a deal it is satisfied with. And none of the other countries in the seven-nation accord has expressed interest in picking apart an understanding that took more than a decade of stop-and-go diplomacy and almost two full years of negotiations to complete.
"We neither mourn nor cheer because it makes no difference to us. We do not have any judgment on the election," Khamenei said. "We are also not worried. And we are ready for any possible incident.
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