Teresa Heinz Kerry, 74, was admitted to the hospital in Boston on Sunday in critical condition, but her situation has improved since then.
Kerry, who was scheduled to return to the Foggy Bottom headquarters of the State Department on Monday, extended his stay in Boston.
"Teresa Heinz Kerry continues to improve and remains in fair condition at Massachusetts General Hospital, while doctors seek the cause of seizure-like symptoms she experienced on Sunday," said Glen Johnson, personal spokesman for John Kerry.
The State Department said Kerry's presence in Washington would depend on the health condition of his wife.
In his absence, Deputy Secretary of State William Burns would lead the State Department's delegation to the US-China Strategic and Economic Dialogue.
"I believe he will be here for the dinner this evening," the State Department spokesperson Jen Psaki told reporters at her daily news conference earlier in the day.
Heinz Kerry is the widow of former US Senator John Heinz, heir to the Heinz ketchup fortune. She married John Kerry in 1995. She was previously treated for breast cancer.
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