The 30-year-old's hospitalisation at Cedars-Sinai Medical Centrer triggered media reports that he was near death, reported CNN online.
Mack Maine, the president of Wayne's label Young Money, thanked the hospital.
"Lil Wayne has been officially been released and is headed home... God is great," he tweeted.
An online report that Wayne was near death and on life support Friday cause panic among his fans and caused the micro-blogging site to light up with messages of concern.
"I'm good everybody. Thanx for the prayers and love," Wayne had tweeted Friday evening.
'Sizzurp' is a mix of cough syrup, hard candy and soft drinks.
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