The 42-year-old "The Departed" actor has rented out the entire five-star Caribbean resort for a reported USD 1 million, reported New York Post.
The guest list includes stars like George Clooney and Stacy Keibler, Ben Affleck and Jennifer Garner.
Damon and his wife wed in a small ceremony at city hall in 2005. The couple have three daughter's - Isabella, Gia Zavala Damon and Stella Zavala Damon - together.