The protesters led by Fatima marched from Parivarta Chowk to Gandhi statue in Hazratganj, demanding justice for her son.
They also shouted slogans against Prime Minister Narendra Modi, Home Minister Rajnath Singh, BJP and RSS.
Najeeb went missing from his hostel on October 15 last year.
They demanded that the authorities take action against nine members of Akhil Bharatiya Vidyarthi Parishad (ABVP), against whom an FIR has already been lodged.
JNU office bearers also participated in the march.
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