The development gives a big advantage to Jeb Bush to make a maiden bid for the White House next year.
"After putting considerable thought into making another run for president, I've decided it's best to give other leaders in the party the opportunity to become our next nominee," Romney told donors in a conference call.
Romney said he is taking such a decision despite knowing that he would win the Republican Party nomination for the 2016 elections.
Romney was defeated by US President Barack Obama in 2012 presidential elections and lost to John McCain in the 2008 Republican primary.
Last week, McCain had told his supporters that he is thinking of making a third bid to the top position.
Romney said he was convinced of victory in the primaries.
"One poll out yesterday shows me gaining support and leading the other contender nearly two to one. Also, leading in all of the more early (primary poll) states," Romney said.
"But that's before the other contenders have had the opportunity to take their message to the voters. I believe that one of our next generation of Republican leaders, one who may not be as well-known as I am today, one who has not yet taken their message across the country. One who's just getting started may well emerge as being better able to defeat the Democrat nominee. In fact, I expect and hope that to be the case," he said.
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