The disaster struck in the early morning when many people in Manizales were still asleep, just as a flooding disaster two weeks ago that caused more than 300 deaths in this Andean nation's southern city of Mocoa.
Dozens of hillsides gave way in Manizales after the city of nearly 400,000 people received the equivalent of a full month's rain in the span of five hours.
Rescuers dug in thick layers of mud searching for nine people listed as missing.
Among those believed buried in the debris was a man trying to help several relatives after water began entering their home. A mudslide wrecked the house while he was still inside, though all of his family members managed to escape.
"Unfortunately, everything indicates he is buried in there," said Juan Carlos Rendon, a transit coordinator aiding operations in Manizales.
The dead included a police officer and two children.
"It rained in Manizales like it has never rained before," Santos said.
The landslides occurred as Colombia is still recovering from the March 31 disaster in Mocoa, and the two incidents drew several immediate parallels. Both caught unsuspecting residents off guard in the early morning hours after the cities received unprecedented amounts of rain. Both also struck hardest at poor people living in precarious housing developments.
One resident, Ana Henao, said she was at home with her 12-year-old daughter Tuesday evening when their roof began to collapse from the intense rains. They stayed awake in fear that worse might still be to come.
When a stream of mud began burying the home, she and her daughter got to safety.
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