New hormone that makes ovaries grow discovered

Scientists have identified a new hormone that promotes follicle development and stimulates ovary growth, and could act as a potential 'game-changer' in human fertility treatment.
The discovery may help improve effectiveness of current fertility treatments for women and possibly lead to entirely new treatments altogether.
Researchers from Stanford and Akira University in Japan identified the hormone called "R-spondin2".
"The finding of a new ovarian hormone produced by the oocytes capable of stimulating ovarian follicle growth could lead to new infertility treatments," said Aaron J W Hsueh, a researcher involved in the work from the Division of Reproductive and Stem Cell Biology in the Department of Obstetrics and Genecology at Stanford University Medical School in Stanford, California.

To make this discovery, Hsueh and colleagues analysed all the proteins likely made by the eggs, and discovered a previously unknown hormone, called R-spondin2.
The researchers then replicated this new hormone in test tubes and injected it into mice.

The hormone stimulated growth of mouse ovarian cells, leading to the generation of mature eggs, researchers said in the FASEB Journal.
These eggs were fertilised and led to successful pregnancies and the delivery of healthy pups. Then, human ovarian tissue was grafted into mice, and this also grew after treatment with this newly identified ovarian hormone, suggesting that the hormone could work in humans.

The researchers speculated that when used in conjunction with the traditional Follicle Stimulating Hormone (FSH), this newly discovered ovarian hormone could lead to new infertility treatment options for those not responding well to FSH treatment alone.
"Infertility can be very frustrating for couples who have been trying to conceive for a very long time. The discovery of this new hormone is a potential game-changer in human fertility treatment," said Gerald Weissmann, Editor-in-Chief of The FASEB Journal.
However, he added that further research is needed to determine its efficacy and safety in humans.