The charity said the report, which is endorsed by humanitarian Graca Machel, former UN chief Kofi Annan and Nobel economist Joseph Stiglitz, was the "opening salvo" of a new campaign to force world leaders to take action.
"Far from being a driver of economic growth, extreme inequality is a barrier to prosperity for most people on the planet," said Winnie Byanyima, Oxfam International's executive director.
"Today wealth is trickling upwards, and will continue to do so until governments act. We should not allow narrow-minded economic doctrine and the self-interest of the rich and powerful blind us to these facts," she added.
According to the report, 70 per cent of people live in countries where the gap between poor and rich has widened over the last 30 years while inequality of individual wealth has become even more extreme.
It calculated that the wealth of the world's 85 richest people grew USD 668m each day.
"If Bill Gates were to cash in all of his wealth, and spend USD 1m every single day, it would take him 218 years to spend it all," it said.
Stiglitz warned that today's level of inequality "harms our economies our societies, and undermines our politics."
The report called for drastic action to reverse the trend, which it blames on "market fundamentalism" and the capture of legislatures by wealthy elites.
"The potential benefit of curbing runaway wealth by even a tiny amount also tells a compelling story," it said.
"Oxfam has calculated that a tax of just 1.5 per cent on the wealth of the world's billionaires, if implemented directly after the financial crisis, could have saved 23 million lives in the poorest 49 countries by providing them with money to invest in health care," the report said.
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