Speaking during his first pastoral visit to northern Italy, the pontiff slammed hostility towards migrants arriving by boat from Libya, with European countries bickering over who should be forced to provide shelter to the needy.
"It brings tears to one's eyes to see the spectacle of these days, in which human beings have been treated like merchandise," he told the crowds.
He was speaking as Italian Prime Minister Matteo Renzi met his French counterpart Francois Hollande in Milan to discuss the immigration crisis which has seen hundreds of migrants blocked on the border between the two countries.
Francis, whose father grew up in the city, was in Turin to pray before the mysterious shroud, believed by Christians to be the burial cloth of Jesus but held by sceptics to be a medieval fake.
Sitting before it in silence in the city's cathedral, Francis remained with his head bowed in prayer before rising to contemplate up close the linen cloth which bears the faint image of a man who appears to have died by crucifixion.
The Church sidesteps the issue by calling the venerated cloth a religious icon.
The shroud "encourages us to consider the faces of everyone who suffers and is unjustly persecuted," the pontiff said during his Angelus prayer.
In Italy, criminal networks have been preying on refugees, exploiting them to pocket government subsidies, while the northern regions in particular have begun closing their doors to asylum seekers.
Nor should locals turn their backs on their own poor, elderly and unemployed, he said, pointing out that 10 per cent of the region lives in poverty, while 40 per cent of young people are jobless and the elderly feel abandoned.
"We are called to say 'no' to the idolatry of money," which pushes people to try by any means to get rich despite the crisis, "without caring for the many getting poorer, sometimes to the point of hunger," he said.
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