Francis, who was on his way home today from his South America trip, said he was concerned about the negotiations and that "it would be an ugly thing" if the talks do not go ahead.
"We are always disposed to help, we have so many ways to help," he told reporters.
Colombia's government and leftist rebels announced yesterday they had agreed to accelerate peace negotiations and will attempt to negotiate a cease-fire even before reaching an agreement to bring an end to the country's five-decade-old conflict.
In comments to reporters aboard the papal plane, Francis was more circumspect about wading into Bolivia's longstanding border dispute with Chile. Bolivia lost its access to the Pacific Ocean during the War of the Pacific with Chile in 1879-83.
Bolivia has recently taken its bid to renegotiate access to the Pacific to the International Court of Justice, which hasn't yet ruled on whether it will take the case.
During his visit, Francis stressed the need for dialogue among all countries in Latin America, especially with reference to the sea dispute. He was asked yesterday to go farther, and whether he supported Bolivia's bid to change its borders.
Overall, he praised the Latin American church as young and fresh, and said that the rest of the world can learn from it.
"I've wished to give encouragement to this young church and I believe that this church can give us much. It can also be an undisciplined church but with time it will become disciplined. But it will give us so much good," he said.