Police confiscated a record 98 million tablets, nearly double the 50 million seized in 2015, according to police data.
Myanmar is one of the world's top drug-producing nations, churning out huge quantities of methamphetamine and other synthetic drugs as well as heroin, opium and cannabis -- much of it bound for consumers in Asia and beyond.
Most production takes place in remote border territories controlled by ethnic minority militias or rival armed groups allied to the powerful military.
Given the powerful vested interests involved, tackling the trade remains a major hurdle for the newly installed civilian administration of Aung San Suu Kyi.
In addition to the tablets, documents show some 759 kilogrammes of heroin, 945 kilogrammes of opium and 2,464 kilogrammes of pure methamphetamine -- or "ice" -- were seized last year.
Drug prosecutions jumped from some 8,800 in 2015 to 13,500.
Narcotics officers say the latest figures show policing is making inroads into the problem.
"But still trafficking is increasing," one senior officer told AFP, asking not to be named.
Neighbouring Thailand today announced two major drug seizures made during raids last week.
In the southern province of Hat Yai police found 87 kilogrammes of methamphetamine and 25 kilogrammes of cannabis.
They also confiscated 720,000 amphetamine tablets and arrested three local suspects in a raid in the northeastern province of Udon Thani.
Officers said the three men were part of a network run by Xaysana Keopimpha, a Laos national detained at Bangkok's main airport last month and described by Thai police as a regional drug kingpin.
While seizures are fairly common, analysts say the overall battle is hampered by endemic official corruption and drug syndicates' ability to bounce back from raids with ramped-up production.
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