Aleppo was left out of the temporary US-Russian brokered truce, which appeared intact in the regime stronghold of Latakia as well as Damascus and the nearby rebel bastion of Eastern Ghouta.
In Aleppo's rebel-held east, dozens of civilians left the battered district of Bustan al-Qasr early today morning, an AFP correspondent said.
"The situation has become unbearable," Abu Mohammed said as he prepared to flee with his wife and five children.
"One of my kids is terrified by the bombing and no one has been buying anything from my shop for a week," said the household appliance salesman. "Everything is paralysed."
The city has been divided between regime control in the west and rebel control in the east since 2012.
More than 246 civilians have died in shelling, rocket fire and airstrikes in both sides of the city since April 22, the Syrian Observatory for Human Rights monitor said.
At least six civilians died in rebel-controlled areas today, including Bab al-Nairab and Bustan al-Qasr districts, the civil defence said.
The few people out on the streets in the city's east watched the sky anxiously for regime aircraft, running for shelter when one launched a new raid.
Some families have fled to safer districts nearby. Others left by the dangerous Castello road, the only route out of near-besieged east Aleppo that has been targeted by airstrikes and shelling.
Hospitals have also been bombed in nine days of escalating violence in Aleppo. Four medical facilities were hit in Aleppo yesterday on both sides of the front line, according to the International Committee of the Red Cross.
A raid on Wednesday hit a hospital supported by Doctors Without Borders and the Red Cross as well as a nearby housing, killing 30 people in an attack UN chief Ban Ki-moon condemned as "inexcusable".
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