The 74-year-old Vermont Senator, Sanders, easily won the primary in West Virginia by more than 15 percentage points but acknowledged that he has an uphillclimb in terms of becoming the party's nominee.
Sanders' win is unlikely to prevent the 68-year-old former secretary of state from emerging as the presumptive Democratic nominee, given that she has a massive lead over him in the delegates count, but at the same time ensuring that Clinton's ticket for the race to the White House is not a cake walk.
Sanders has won 19 states to Clinton's 23, but she is 94% through the way to winning the nomination - just 144 delegates short of the 2,383 required.
As a consolation, Clinton won the Nebraska primary, but she is not getting any delegate from it. The delegates were allocated in the March 5 primary, which was won by Sanders. Clinton received 10 delegates as against Sanders' 15.
Addressing a rally in Salem, Oregon after the victory, Sanders said: "We now have won primaries and caucuses in 19 states. Let me be as clear as I can be. We are in this campaign to win the Democratic nomination."
He, however, acknowledged that he has an uphillclimb in terms of becoming the party's nominee, but said he would continue his fight till the end of the primary season. He also hinted that he would seek to unite the party in a general election if he fails to win the nomination.
"While we have many disagreements with Secretary Clinton, there is one area where we agree and that is we must defeat Donald Trump."
In the Republican camp, the sole candidate Trump won both the primaries in West Virginia and Nebraska taking his total delegate count to 1,107.
Trump now needs just 130 delegates to officially become the presidential nominee of the party in July.
After the win, the 69-year-old real estate tycoon tweeted: "Thank you West Virginia!" and "Thank you Nebraska!"
"It is a great honour to have won both West Virginia and Nebraska, especially by such massive margins. My time spent in both states was a wonderful and enlightening experience for me," Trump said in a statement.
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