The experimental Solar Impulse plane -- with the wingspan of a Boeing 747 but the weight of a small car -- bears 12,000 solar cells.
By day, the cells power the plane's electric motors while also charging batteries, so the plane, unlike other solar aircraft, can keep flying all night.
The project was launched over a decade ago, after inveterate adventurer Bertrand Piccard, 54, nearly ran out of fuel on his historic non-stop round-the-world balloon flight.
"Adventure in the 21st century consists in using human creativity and the pioneering spirit to develop the quality of life to which present and future generations are entitled," he said in a statement, explaining his philosophy.
The Solar Impulse plane has already made several trips, including a 26-hour flight in 2010, but this is its first trip across a continent.
The plane could make the flight nonstop -- it would take approximately three days, travelling at the aircraft's cruising speed of around 70 kilometres per hour, its creators said.
That will allow two pilots -- Piccard and his co-founder, Swiss engineer and ex-fighter pilot Andre Borschberg -- to share duties and rest between legs.
"We have limited ourselves to fly a duration maximum of 24 hours," Borschberg, 60, said at a press conference in March.
The plane is scheduled to stay over in Phoenix, Dallas and Washington, D.C. Before arriving in New York in early July.
"The people will be able to follow the mission, to speak to the pilot, to ask questions," Piccard said.
"We would like to inspire students, schoolchildren, inspire as many people as possible to try to have the spirit to dare, to innovate, to invent," he added.
