"The preliminary toll in the terrorist suicide bombing at the old palace of justice building is 25 dead and a number of wounded," state news agency SANA reported, citing a Damascus police source.
An AFP correspondent at the scene in the Hamidiyeh neighbourhood said security forces had cordoned off the area and roads leading to it were blocked as ambulances and firefighters rushed to the building.
The courthouse contains both an Islamic religious tribunal charged with personal matters, and a criminal court.
"We took refuge in the library which is on a higher floor," the lawyer added, speaking on condition of anonymity.
"It was a bloody scene."
A local prosecutor told state television: "The terrorist targeted civilians... During a crowded period.
"The suicide bomber tried to enter and when police tried to prevent him, he rushed inside and blew himself up," the prosecutor added.
The bombing comes on the sixth anniversary of the Syrian conflict, which began with anti-government demonstrations in March 2011.
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