Hosted in the Kazakh capital Astana, the talks will see an opposition delegation composed exclusively of rebel groups negotiating with the regime of President Bashar al-Assad in an initiative sponsored by rebel backer Turkey and regime allies Russia and Iran.
Though the talks have been welcomed by all parties in the conflict, delegates from both sides are heading to Kazakhstan with apparently opposing ideas about the goals, with Assad insisting Thursday that rebels lay down their arms in exchange for an amnesty deal.
The rebels meanwhile say they will focus solely on reinforcing a frail nationwide truce brokered by Moscow and Ankara last month.
Moscow said this week that the objective was to "consolidate" the ceasefire and involve rebel field commanders in the "political process" to end the bloodshed, creating a basis for a new round of UN-hosted negotiations in Geneva next month.
Syria's UN ambassador Bashar al-Jaafari, an experienced negotiator involved in past failed talks in Geneva, will head the regime delegation in Astana.
Mohammad Alloush of the Jaish al-Islam (Army of Islam) rebel group -- whose commander cousin Zahran Alloush was killed in an air strike claimed by the regime in December 2015 -- will lead a "military delegation" of around eight people.
They will be backed by nine legal and political advisors from the opposition High Negotiations Committee (HNC) umbrella group.
But key rebel group Ahrar al-Sham said it would snub the Astana talks over ceasefire violations and ongoing Russian air strikes on the country.
The talks, which could last days, come a month after the Syrian regime, bolstered by its allies, took full control of second city Aleppo from rebels in its biggest victory in more than four years of fighting.
With stakes high and outcomes unclear, the Syrian opposition is wary that the regime could use the rebel groups' inexperience in political talks to its advantage in Astana, a European diplomatic source told AFP.
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