Shortly after the blast, the Taliban claimed responsibility for the attack.
The bombing took place in the car park of the Justice Ministry when a car packed with explosives was detonated, said Interior Ministry spokesman Sediq Sediqqi.
He initially said that at least six people were killed but the Interior Ministry later revised the death toll, saying four were killed, following an investigation at the site.
"The report from our investigative team confirms that four people were killed, including a woman, and 24 others were wounded," said Sediqqi.
The 4 pm bombing coincided with the end of the working day, when ministry employees board minibuses in the car park to go home.
The ministry is surrounded by buildings and shops and is located in one of the busiest areas of downtown Kabul.
An Associated Press reporter at the scene said windows in buildings in the area had been blown out, indicating a huge explosion.
An email from the Taliban sent to media organizations in Kabul said the insurgents were behind Tuesday's bombing.
It was third large attack in the capital in the past week. The Taliban said they were behind an attack on a Kabul guesthouse last week that killed 14 people, including nine foreigners, and also a suicide car bombing this week that killed three people, among them two young girls and a British security contractor.
The Taliban launched their spring offensive in late April with attacks across a widespread area of the country in what appears to be a fresh strategy aimed at forcing the government to concentrate its efforts and assets on security -- rather than on much-needed economic reforms.
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