"The deliberate starvation of people is unequivocally forbidden as a weapon of warfare. By extension, so are sieges, which deprive civilians of essential goods such as food," Zeid Ra'ad Al Hussein said.
In an address opening the UN Human Rights Council's main annual session, Zeid pointed to the desperate situation of an estimated 480,000 people "currently trapped in besieged towns and villages in Syria -- and have been, in some cases for years."
But Zeid warned that the situation could be far more dire.
"Thousands of people risk starving to death," he said.
His comments came as the UN was preparing to deliver aid to thousands of besieged civilians in Syria as a fragile ceasefire appeared to be largely holding.
The first major truce in five years of conflict was expected to allow aid workers to bring supplies to an additional 154,000 people living in besieged areas over the next five days.
"Neighbourhoods, schools and packed marketplaces have been hit by tens of thousands of air strikes, thousands of barrel bombs have been thrown out of helicopters onto streets and homes," he said of the conflict which has cost more than 270,000 lives since March 2011.
He also said that some parties "are targeting medical units deliberately, or with reckless disregard," noting that at least 10 hospitals and other medical units have been damaged or destroyed just since the beginning of the year.
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