Many children were among the dead in the explosions that hit two crowded markets and a busy bus station in Maiduguri, the region's largest city and capital of the embattled Borno state.
The Nigerian Islamist militants have relentlessly attacked Maiduguri throughout their six-year uprising, which has cost more than 13,000 lives and security forces in the city have struggled to contain the bloodshed.
Nigeria has since last month claimed key victories over Boko Haram in an offensive being waged in cooperation with forces from neighbouring Cameroon, Chad and Niger.
A woman with explosives strapped to her body blew herself up at roughly 11:20 am (1020 GMT) when she got out of a motorised rickshaw at Maiduguri's Baga fish market, said the head of the fisherman's union, Abubakar Gamandi, who was at the scene.
"The bomb was devastating because it occurred at a crowded area," said Jamuna Jarmi, a grocery seller.
About an hour later another blast rocked the popular Monday Market, causing chaos as locals voiced anger at security forces who struggled to control the scene.
Just after 1:00 pm a third blast hit a used car lot which is attached to the busy Borno Express bus terminal.
There were indications that the second and thirds blasts were also carried out by suicide bombers but details were not immediately clear.
"Normalcy has been restored," he added, declining to give further details.
Gamandi, who was supporting rescue workers at Maiduguri General Hospital, told AFP that "the dead include women and children" but said most of the victims were men.
