A statement from the US Department of Health and Human Services confirmed that it had accepted the resignation of CDC director Brenda Fitzgerald.
"Dr Fitzgerald owns certain complex financial interests that have imposed a broad recusal limiting her ability to complete all of her duties as the CDC director," said the statement by spokesman Matt Lloyd.
"Due to the nature of these financial interests, Dr. Fitzgerald could not divest from them in a definitive time period."
Among the CDC's top responsibilities is reducing smoking, which is a top killer and leading cause of lung cancer and heart disease.
Fitzgerald, a medical doctor and former Georgia Department of Public Health commissioner, has long publicly championed anti-smoking efforts.
She became CDC chief on July 7, 2017.
That same month, and in August and September, she "bought tens of thousands of dollars in new stock holdings in at least a dozen companies," Politico reported.
"Purchases included between USD 1,001 and USD 15,000 of Japan Tobacco, one of the largest such companies in the world, which sells four tobacco brands in the US through a subsidiary."
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