The rapper's greatest hits will be used for a non-biographical stage production called 'Holler If Ya Hear Me', which will open at the Palace Theatre in New York this June, reported Digital Spy.
The title of the musical is a reference to Tupac's 1992 single of the same name, which featured samples from Public Enemy, Funkadelic and George Clinton.
The plot of 'Holler If Ya Hear Me' will centre around two friends from the Midwest and their inner city lives.
Tupac's mother Afeni Shakur is producing the show, while Kenny Leon will direct.