Speaking to foreign reporters at his Istanbul offices in the Ottoman-era Dolmabahce Palace on the Bosphorus, Davutoglu said he was nonetheless ready to work with Moscow to prevent a repeat of the November 24 incident.
"Russia is trying to make ethnic cleansing in the northern Latakia (region) to force (out) all Turkmen and Sunni populations who do not have good relations with the (Syrian) regime," Davutoglu told foreign reporters in Istanbul.
"They want to expel, they want to ethnically cleanse this area so that regime and Russian bases in Latakia and Tartus are protected," he said.
"They don't want to see any Sunni Arab or Turkmen population in that part of Syria. That is the purpose," Davutoglu said.
The region is a stronghold of Alawite Muslims loyal to the Kremlin's ally President Bashar al-Assad who Ankara wants to see ousted.
Davutoglu also said that Russia's military strikes in Syria, which began in late September, were "strengthening" IS jihadists by targeting moderate forces opposing Assad, especially around Azaz in northern Syria.
He said Russia was bombing Azaz "which is a stronghold of moderate opposition against Daesh".
"They are bombing Azaz to weaken the opposition, who is fighting Daesh. It means they (Russia) are strengthening Daesh.
"Who is benefitting from this? Daesh. Not even the regime. Daesh."
Davutoglu said just 10 per cent of Russia's strikes in Syria targeted IS whereas 90 per cent targeted "moderate forces" opposed both to Assad and the jihadists.
He said the Russian actions were affecting plans for joint operations with the US and moderate Syrian rebels to secure the border from jihadists.
