Dewani was escorted to the Western Cape High Court, where he appeared for the first time in a South African court, according to Mthunzi Mhaga, spokesperson of the Department of Justice and Constitutional Development.
There he was formally charged and processed by the investigating team.
Dewani, 34, was charged with murder and will face charges relating to conspiracy to commit murder and defeating the ends of justice.
He landed in Cape Town on a chartered flight procured by the department.
Dewani was put on the flight to Cape Town from Heathrow yesterday to face a charge for ordering the contract killing of his 28-year-old wife Anni, which he denies.
He was taken from Fromeside Hospital in the British city of Bristol, to the airport by officers from the Metropolitan Police Service Extradition Unit.
They were met at the airport by officials from the South African authorities who escorted him to the flight
His extradition comes after three years of a protracted legal battle to keep the Bristol-based businessman in the UK.
Dewani's lawyers had argued that he should not be forced from the UK to face trial until he recovers from mental health problems, including depression and post-traumatic stress disorder.
But in March, judges at the High Court here rejected all his grounds for appeal against his removal from the UK and denied him the chance to take the case to the Supreme Court.
His initial assessment will be for 30 days but an agreement between British and South African authorities will see the businessman returned to the UK in 18 months if deemed unfit to stand trial.
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