The joint appeal from the UN's refugee agency, humanitarian aid coordinator OCHA, children's agency UNICEF, the World Food Program and the World Health Organization urged for an "immediate, unconditional and safe access" to all Syrian families and children in need.
According to the statement, up to 700,000 people nearly half of them children live in 15 besieged areas of Syria.
Many lack "the most basic elements to sustain their lives" and face "continued risk of violence," said the statement, which came from Davos in Switzerland, where business, political, cultural elites and non-governmental group leaders are gathering for the World Economic Forum.
Last month, Russian air power helped forces supporting Syrian President Bashar Assad crush the opposition-held enclave in the northern city of Aleppo, a major win for Assad's forces, which had besieged the rebels for months.
"The horrors of the siege of the eastern districts of Aleppo have disappeared from the public consciousness but we must not let the needs, the lives and the futures of Syria's people fade from the world's conscience," the UN agency chiefs said in the statement.
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