A local official, and Syrian state television, accused the US-led coalition fighting the Islamic State group of carrying out the strikes, and gave a lower death toll of 14, with 30 injured yesterday.
IS holds part of the city, but the deaths came in a neighbourhood under government control and appeared to be the possible result of a mistake, the Britain-based Syrian Observatory for Human Rights said.
The war monitor said the 22 civilians were killed in the Al-Qusur neighbourhood, in the west of the city, which is provincial capital of oil-rich Deir Ezzor province.
"Fourteen civilians were killed and more than 30 others injured in air strikes by coalition planes on the Al-Qusor neighbourhood in Deir Ezzor city," the source said, adding that the toll could rise because a number of the injured were in serious condition.
Syrian state television, citing its reporter, also accused the coalition of the strikes.
There was no immediate response from the coalition to questions on the deaths, which were reported late last night.
Syrian regime forces backed by ally Russia have seized most of Deir Ezzor city after breaking an IS siege of nearly three years on government-held districts in September.
A second, separate offensive against the jihadists is being fought on the eastern side by the Kurdish-Arab Syrian Democratic Forces, backed by the US-led coalition against IS.
A "deconfliction" mechanism is meant to keep the two campaigns separate.
IS controls less than half of Deir Ezzor province, its last remaining stronghold in the country after the SDF ousted it from its bastion Raqa last week with US-led coalition support.
More than 330,000 people have been killed in Syria since the war began in March 2011 with anti-government protests.
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