"The agreement represents a potentially significant step toward a peaceful resolution of the conflict and the restoration of Ukraine's sovereignty," the White House said in a statement.
The deal was negotiated between leaders of Germany, France, Russia and Ukraine after marathon talks that ended early Thursday.
The ceasefire is due to take effect on February 15.
It would create a 50 kilometer buffer zone and force the withdrawal of troops and heavy artillery from the front line, under the eye of monitors from the OSCE.
"The true test of today's accord will be in its full and unambiguous implementation," the White House said.
That would include "the durable end of hostilities and the restoration of Ukrainian control over its border with Russia," President Barack Obama's administration said.
The agreement comes amid a fresh wave of hostilities on the ground that could call the deal into question even before the ink is dry.
The White House said it was "particularly concerned about the escalation of fighting today, which is inconsistent with the spirit of the accord.
