Why people get aggressive after drinking decoded

Just two glasses of vodka can trigger changes in the brain region linked to aggression, say scientists who used MRI scans to understand why people become violent after consuming alcohol.
According to most theories, alcohol-related aggression is caused by changes in the prefrontal cortex. However, there is a lack of substantial neuroimaging evidence to substantiate these ideas.
For the study led by Thomas Denson of the University of New South Wales in Australia, researchers recruited fifty healthy young men.
The participants were either given two drinks containing vodka, or placebo drinks without any alcohol.
While lying in an MRI scanner, the participants then had to compete in a task which has regularly been used over the past 50 years to observe levels of aggression in response to provocation.

The functional magnetic resonance imaging (fMRI) allowed the researchers to see which areas of the brain were triggered when the task was performed.

They could also compare the difference in scans between participants who had consumed alcohol and those who had not.
Being provoked was found to have no influence on participants' neural responses.
However, when behaving aggressively, there was a dip in activity in the prefrontal cortex of the brains of those who had consumed alcoholic drinks.
This dampening effect was also seen in the areas of the brain that are involved reward, according to the study published in the journal Cognitive, Affective and Behavioral Neuroscience

Also, heightened activity was noted in the hippocampus, the part of the brain associated with people's memory.
"Although there was an overall dampening effect of alcohol on the prefrontal cortex, even at a low dose of alcohol we observed a significant positive relationship between dorsomedial and dorsolateral prefrontal cortex activity and alcohol-related aggression," said Denson.
"These regions may support different behaviours, such as peace versus aggression, depending on whether a person is sober or intoxicated," he said.
The results are largely consistent with a growing body of research about the neural basis of aggression, and how it is triggered by changes in the way that the prefrontal cortex, the limbic system and reward-related regions of the brain function.

The results of the current study are also consistent with several psychological theories of alcohol-related aggression.
"We encourage future, larger-scale investigations into the neural underpinnings of alcohol-related aggression with stronger doses and clinical samples. Doing so could eventually substantially reduce alcohol-related harm," said Denson.