Seven-time Wimbledon Champion Roger Federer bowed out of the US Open with a straight-set loss to Spain's Tommy Robredo 6-7, 3-6, 4-6, while his rival Rafael Nadal too struggled but got through against Germany's Philipp Kohlschreiber, winning 6-7, 6-4, 6-3, 6-1.
Frenchman Richard Gasquet prevailed in an epic five-setter against Canadian Milos Raonic, winning 6-7, 7-6, 2-6, 7-6, 7-5.
In other matches, Italy's Roberta Vinci, once again made the quarterfinals with a 6-4, 6-2 win over compatriot Camila Giorgi and Simona Halep bowed out with a 2-6, 6-7 loss to Italy's Flavia Pennetta.
Spain's David Ferrer and Slovakia's Daniela Hantuchova won their matches to go through to the next round.
